This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.
Immunogen Information
Immunogen
Synthetic peptide of human PDCD1
Swissprot
Q15116
Synonyms
CD279CD279 antigenhPD 1hPD lhPD-1hSLE1PD 1PD-1PD1PDCD 1PDCD1PDCD1Programmed cell death 1Programmed cell death 1 proteinProgrammed cell death protein 1Protein PD 1Protein PD-1SLEB2Systemic lupus erythematosus susceptibility 2
Gene Accession
NP_005009
Applications
Reactivity
Human
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.5 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4