This gene encodes the delta subunit of rod-specific photoreceptor phosphodiesterase (PDE), a key enzyme in the phototransduction cascade. A similar protein in cow functions in solubilizing membrane-bound PDE. In addition to its role in the PDE complex, the encoded protein is thought to bind to prenyl groups of proteins to target them to subcellular organelles called cilia. Mutations in this gene are associated with Joubert syndrome-22. Alternative splicing results in multiple splice variants.
Immunogen Information
Immunogen
Fusion protein of human PDE6D
Swissprot
O43924
Synonyms
5''-cyclic phosphodiesterase subunit deltaGMP PDE deltaGMP-PDE deltap17 proteinPDE 6PDE 6DPDE DPDE6PDE6DPDE6DPDEDPhosphodiesterase 6D cGMP specificPhosphodiesterase 6D cGMP specific rod deltaProtein p17Retinal rod photoreceptor cGMP phosphod