PE/AF594 Anti-Human CD49d Antibody

For reference only. Please follow the manual included in your kit for instructions.

Catalog Number
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Overview

Circle
Product Name
PE/AF594 Anti-Human CD49d Antibody
Catalog Number
RD30321F
Clonality
Monoclonal
Isotype
Mouse IgG1, κ
Host
Mouse

Background

Circle
CD49d is a 150 kD α integrin chain known as α4 integrin or VLA-4 α chain. It forms a heterodimer with either integrin β1 (α4β1, VLA-4) or β7 (α4β7). CD49d is expressed broadly on T lymphocytes, B lymphocytes, monocytes, thymocytes, eosinophils, basophils, mast cells, NK cells, dendritic cells, and some non-hematopoietic cells, but not on normal red blood cells, platelets or neutrophils. VLA-4 binds to VCAM-1 (CD106) and fibronectin. α4β7 is the receptor for VCAM-1 and MAdCAM-1. CD49d participates in mononuclear cell trafficking to endothelial sites of inflammation and has roles in cell-cell interactions and cell adhesion to extracellular matrices. CD49d is involved in lymphocyte migration, T cell activation, and hematopoietic stem cell differentiation. CD49d is a marker to isolate pure populations of Treg cells due to its absence on Foxp3+ cells.

Immunogen Information

Circle
Gene ID
3676
Swissprot
P13612
Synonyms
Integrin alpha-4CD49 antigen-like family member DIntegrin alpha-IVVLA-4 subunit alphaCD49dITGA4

Applications

Circle
Reactivity
Human
Tested Applications
FCM
Conjugation
PE/AF594
Storage Buffer
PBS with 0.05% Proclin300, 1% BSA
Storage Instructions
Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.

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