PE Anti-Human CD45 Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD21698F
Human peripheral blood lymphocytes are stained with Anti-Human CD45 Monoclonal Antibody(PE Conjugated)(filled gray histogram). Unstained lymphocytes (empty black histogram) are used as control.
Product Name
PE Anti-Human CD45 Antibody
Catalog Number
RD21698F
Clonality
Monoclonal
Isotype
Mouse IgG1, κ
Host
Mouse
Background
CD45 is a 180 - 240 kD single chain type I membrane glycoprotein also known as leukocyte common antigen (LCA) and T200. It is a tyrosine phosphatase expressed on the plasma membrane of all hematopoietic cells, except erythrocytes or platelets. CD45 is a signaling molecule that regulates a variety of cellular processes including cell growth, differentiation, cell cycle, and oncogenic transformation. CD45 plays a critical role in T and B cell antigen receptor-mediated activation by dephosphorylating substrates including p56Lck, p59Fyn, and other Src family kinases. CD45 non-covalently associates with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. CD45 has been reported to bind galectin-1 and to be associated with several other cell surface antigens including CD1, CD2, CD3, and CD4.
Immunogen Information
Gene ID
5788
Swissprot
P08575
Synonyms
Receptor-type tyrosine-protein phosphatase CPtprcL-CALy-5T200CD45
Applications
Reactivity
Human
Tested Applications
FCM
Conjugation
PE
Storage Buffer
PBS with 0.05% Proclin300, 1% BSA
Storage Instructions
Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.