PE Anti-Human CD74 Antibody

For reference only. Please follow the manual included in your kit for instructions.

Catalog Number
Human peripheral blood lymphocytes are stained with Anti-Human CD74 Monoclonal Antibody(PE Conjugated)(filled gray histogram). Unstained lymphocytes (empty black histogram) are used as control.
Human peripheral blood lymphocytes are stained with Anti-Human CD74 Monoclonal Antibody(PE Conjugated)(filled gray histogram). Unstained lymphocytes (empty black histogram) are used as control.
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Overview

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Product Name
PE Anti-Human CD74 Antibody
Catalog Number
RD20862F
Clonality
Monoclonal
Isotype
Mouse IgG1, κ
Host
Mouse

Background

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CD74 is a type II transmembrane glycoprotein also known as MHC class II associated invariant chain, invariant chain, Ii, MHC class II chaperone, and MIF receptor. CD74 exists in four isoforms with molecular masses of 33, 35, 41, and 43 kD, depending on genetic splicing. CD74 is primarily expressed on antigen presenting cells, including B cells, monocytes/macrophages, dendritic cells, and Langerhans cells. It is also expressed by activated T cells and activated endothelial and epithelial cells as well as carcinomas of lung, renal, gastric and thymic origin. The primary function of CD74 is intracellular sorting of MHC class II molecules and regulation of exogenous peptide loading onto MHC class II. It is also involved in the modulation of B cell differentiation and positive selection of CD4+ T cells. It has been reported that CD74 binds MIF (macrophage migration inhibitory factor) and signals through CD44 to regulate innate and adaptive immunity. It is also reported that H. pylori infection occurs through urease B binding of CD74 on gastric epithelial cells, inducing gastric epithelial cell apoptosis, NF-κB activation, and IL-8 production.

Immunogen Information

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Gene ID
972
Swissprot
P04233
Synonyms
HLA class II histocompatibility antigen gamma chainCD74Ia antigen-associated invariant chainIip33DHLAG

Applications

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Reactivity
Human
Tested Applications
FCM
Conjugation
PE
Storage Buffer
PBS with 0.05% Proclin300, 1% BSA
Storage Instructions
Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.

Research Areas

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