Rat splenocytes are stained with Anti-Rat CD3 Monoclonal Antibody(PE Conjugated)[Used at 0.05 μg/106 cells dilution](filled gray histogram). Unstained splenocytes (empty black histogram) are used as control.
CD3 is a complex composed of δ, γ, ε, and ζ chains. They are 20-25 kD members of the immunoglobulin superfamily and associated with the T cell receptor (TCR). CD3 is expressed on thymocytes, peripheral T cells, some NK-T cells, and dendritic epidermal T cells. CD3 is involved in antigen recognition, signal transduction, and T cell activation.