Human peripheral blood lymphocytes are stained with FITC Anti-Human CD4 Antibody and PE/Cyanine5 Anti-Human CD62L Antibody[HI62L] (Left). Lymphocytes are stained with FITC Anti-Human CD4 Antibody and PE/Cyanine5 Mouse IgG2a, κ Isotype Control (Right).
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Overview
Product Name
PE/Cyanine5 Anti-Human CD62L Antibody[HI62L]
Catalog Number
RD30723F
Isotype
Mouse IgG2a, κ
Host
Mouse
Background
CD62L is a 74-95 kD single chain type I glycoprotein referred to as L-selectin or LECAM-1. It is expressed on most peripheral blood B cells, subsets of T and NK cells, monocytes, granulocytes, and certain hematopoietic malignant cells. CD62L binds to carbohydrates present on certain glycoforms of CD34, glycam-1, and MAdCAM-1 and with a low affinity to anionic oligosaccharide sequences related to sialylated Lewis X (sLex, CD15s) through its C-type lectin domain. CD62L is important for the homing of na?ve lymphocytes to high endothelial venules in peripheral lymph nodes and Peyer's patches. It also plays a role in leukocyte rolling on activated endothelial cells.
Immunogen Information
Gene ID
6402
Synonyms
L-selectinSellCD62 antigen-like family member LLAM-1LECAM1Lymph node homing receptorLy-22CD62LLnhrLy22