PE/Cyanine5 Anti-Mouse CD122 Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD20464F
C57BL/6 murine splenocytes are stained with Anti-Mouse CD122 Monoclonal Antibody(PE/Cyanine5 Conjugated) and Anti-Mouse CD3 Monoclonal Antibody(AF488 Conjugated)(left). Splenocytes stained with Anti-Mouse CD3 Monoclonal Antibody(AF488 Conjugated)(right) are used as control.
Product Name
PE/Cyanine5 Anti-Mouse CD122 Antibody
Catalog Number
RD20464F
Clonality
Monoclonal
Isotype
Rat IgG2a, κ
Host
Rat
Background
CD122 is a 70-75 kD IL-2 receptor β chain also known as IL-2Rβ, which is also shared by the IL-15 receptor. It is constitutively expressed by NK cells and at lower levels by T cells, B cells, monocytes, and macrophages. The IL-2Rβ chain can combine with either the common γ subunit (γc, CD132) alone or with the γc subunit and the IL-2Rα subunit (CD25) to generate intermediate or high affinity IL-2 receptor complexes, respectively. CD122 expression levels can be upregulated by activation. The 5H4 antibody does not block IL-2 binding to the IL-2 receptor. CD122 is expressed on murine, but not human, CD8+ Tregs involved in the maintenance of T cell homeostasis.
Immunogen Information
Gene ID
16185
Swissprot
P16297
Synonyms
Interleukin-2 receptor subunit betaIl2rbIL-2 receptor subunit betaIL-2R subunit betaIL-2RBHigh affinity IL-2 receptor subunit betap70-75CD122
Applications
Reactivity
Mouse
Tested Applications
FCM
Conjugation
PE/Cyanine5
Storage Buffer
PBS with 0.05% Proclin300, 1% BSA
Storage Instructions
Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.
Research Areas