Staining of the U266 cell line with PE/Cyanine7 Anti-Human CD138/Syndecan-1 Antibody[B-B4] (filled gray histogram) or PE/Cyanine7 Mouse IgG1, κ Isotype Control (empty black histogram). Total viable cells were used for analysis.
CD138, a member of the syndecan protein family, is a type I integral membrane heparin sulfate proteoglycan also known as Syndecan-1. Syndecan-1 participates in cell proliferation, cell migration, and cell-matrix adhesion via interaction with collagen, fibronectin, and other soluble molecules (such as FGF-basic). It is expressed on normal and malignant human plasma cells, pre-B cells, epithelial cells, and endothelial cells.