PE/Cyanine7 Anti-Mouse CD200 Antibody

For reference only. Please follow the manual included in your kit for instructions.

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Overview

Circle
Product Name
PE/Cyanine7 Anti-Mouse CD200 Antibody
Catalog Number
RD30439F
Clonality
Monoclonal
Isotype
Rat IgG2a, κ
Host
Rat

Background

Circle
CD200 (OX-2 antigen) is a type-1 membrane glycoprotein containing two extracellular Ig-like domains. CD200 a highly conserved type I membrane glycoprotein that is expressed on a variety of cell types including thymocytes, some T cells, endothelial and follicular dendritc cells, B cells, and brain tissue (neurons); but not on NK cells, granulocytes, monocytes, or macrophages. CD200 costimulates T cell proliferation. It may regulate myeloid cell activity in a variety of tissues. CD200 is the ligand for CD200 receptor (CD200R). The CD200 Receptor is restricted to myeloid cells, and it is believed that its engagement with CD200 results in inhibition and/or downregulation of myeloid cell activity. Blocking of CD200/CD200R interactions decreases myeloid cell inhibitory thresholds which results in enhanced immune activation.

Immunogen Information

Circle
Gene ID
4345
Swissprot
O54901
Synonyms
OX-2 membrane glycoproteinOX-2MRC

Applications

Circle
Reactivity
Mouse
Tested Applications
FCM
Conjugation
PE/Cyanine7
Storage Buffer
PBS with 0.05% Proclin300, 1% BSA
Storage Instructions
Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.

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