This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic Nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders.
Immunogen Information
Immunogen
Synthetic peptide of human PER2
Swissprot
O15055
Synonyms
Circadian clock protein PERIOD 2FASPSFASPS1hPER 2hPER2KIAA0347OTTHUMP00000164476PER 2PER2PER2Period 2Period 2 isoform 1Period circadian clock 2Period circadian protein 2Period circadian protein homolog 2Period homolog 2 (Drosophila)Period
Gene Accession
NP_073728
Applications
Reactivity
Human
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:100-1:300
Concentration
0.6 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4