This protein binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. CREB stimulates transcription on binding to the CRE. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Implicated in synchronization of circadian rhythmicity.
Immunogen Information
Immunogen
Synthesized peptide derived from human CREB-1 around the phosphorylation site of Ser133
Swissprot
P16220
Synonyms
Active transcription factor CREBcAMP response element binding protein 1cAMP response element binding proteincAMP responsive element binding protein 1cAMP-responsive element-binding protein 1CREBCREB-1CREB1CREB1Cyclic AMP-responsive element-bindin
Calculated MW
37 kDa
Observed MW
37 kDa
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB,IHC-p,IF,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:100-1:300, IF 1:100-1:300, ELISA 1:5000-1:20000
Concentration
1 mg/mL
Storage Buffer
PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4