This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Immunogen Information
Immunogen
Synthesized peptide derived from human Fusin around the phosphorylation site of Ser339
Swissprot
P61073
Synonyms
C-X-C chemokine receptor type 4CD184CD184 antigenChemokine (C X C motif) receptor 4Chemokine CXC Motif Receptor 4CXC-R4CXCR-4CXCR4CXCR4D2S201EFB22FusinHM89HSY3RRLAP 3LAP3LCR1LESTRLeukocyte derived seven transmembrane domain receptorLeuk
Calculated MW
40 kDa
Observed MW
38 kDa
Applications
Reactivity
Human,Mouse,Rat,Monkey
Tested Applications
WB,IHC-p,IF,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:20000
Concentration
1 mg/mL
Storage Buffer
PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4