Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation. Involved in nuclear translocation.
Immunogen Information
Immunogen
Synthesized peptide derived from human GR around the phosphorylation site of Ser211
Swissprot
P04150
Synonyms
GCCRGCRGCRGCRSTglucocorticoid nuclear receptor variant 1Glucocorticoid receptorGRGRLGrl1nr3c1Nuclear receptor subfamily 3 group C member 1nuclear receptor subfamily 3group Cmember 1 (glucocorticoid receptor)
Calculated MW
86 kDa
Observed MW
95 kDa
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB,IHC-p,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:5000
Concentration
1 mg/mL
Storage Buffer
PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4