This is calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. May play a role in antigen-dependent control of B-cell function. Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin.
Immunogen Information
Immunogen
Synthesized peptide derived from human PKC δ around the phosphorylation site of Thr507
Swissprot
Q05655
Synonyms
CVID9D14Ertd420eKinase PKC deltaKPCDKPCDMAY 1MAY1MGC49908nPKC deltanPKC-deltaPCKdPKC dPKC deltaPKCDPKCdeltaPRKC DPRKC deltaPrkcdProtein Kinase C deltaProtein kinase C delta typeProtein kinase C delta VIIIProtein Kinase CdeltaTyrosine
Calculated MW
77 kDa
Observed MW
78 kDa
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB,IHC-p,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:20000
Concentration
1 mg/mL
Storage Buffer
PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4