This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1.
Immunogen Information
Immunogen
Synthetic peptide of human PIAS2
Swissprot
O75928
Synonyms
Androgen receptor interacting protein 3Androgen receptor-interacting protein 3ARIP3DAB2 interacting proteinDAB2-interacting proteinDIPE3 SUMO protein ligase PIAS2E3 SUMO-protein ligase PIAS2MIZMiz1Msx interacting zinc finger proteinMsx-interact
Gene Accession
NP_004662
Applications
Reactivity
Human,Mouse
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.6 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4