Phosphatidylinositol-4-phosphate-5-kinase (PIPK) synthesizes phosphatidylinositol-4,5-bisphosphate, which regulates various processes including cell proliferation, survival, membrane trafficking, and cytoskeletal organization. The PIPK family is divided into type I, type II and type III . Each type of the PIPK family phosphorylate distinct substrates and they contain an activation loop, which determines their enzymatic specificity and subcellular targeting . The phosphatidylinositol-4-phosphate-5-kinase type I consists of three members, PIPK I , ∫, and , which are characterized by phosphorylating PI4P on the 5-hydroxyl . PIPK I (designated PIPK I ∫ in mouse) is expressed in brain tissue . PIPK I ∫, designated PIPK I a in mouse, is also called STM7. PIPK I has two variants produced by alternative splicing which are expressed in lung, brain, and kidneys.
Immunogen Information
Immunogen
Recombinant protein of human PIP5K1B
Swissprot
O14986
Synonyms
MSS 4MSS4Phosphatidylinositol 4 phosphate 5 kinase type 1 betaPhosphatidylinositol-4-phosphate 5-kinase type I betaPhosphatidylinositol-4-phosphate 5-kinase type-1 betaPI4P5K 1 betaPI51BPIP5K1-betaPIP5K1BPIP5KIbetaPipk 5 betaPipk 5bProtein ST
Gene Accession
BC030587
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.3 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4