This gene encodes a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways. It plays a role in renal tubular development, and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1).
Immunogen Information
Immunogen
Synthetic peptide of human PKD1
Swissprot
P98161
Synonyms
Autosomal dominant polycystic kidney disease 1 proteinAutosomal dominant polycystic kidney disease protein 1nPKC-D1nPKC-muOTTHUMP00000208669OTTHUMP00000208670PBPPc-1PKDPkd1PKD1Polycystic Kidney Disease 1polycystic kidney disease-associated pro
Gene Accession
NP_001009944
Applications
Reactivity
Human,Mouse
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.2 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4