PLA2G16 Polyclonal Antibody

For reference only. Please follow the manual included in your kit for instructions.

Catalog Number
RD253452A
Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue  using PLA2G16 Polyclonal Antibody at dilution of 1:40(×200)
Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PLA2G16 Polyclonal Antibody at dilution of 1:40(×200)
Immunohistochemistry of paraffin-embedded Human tonsil tissue  using PLA2G16 Polyclonal Antibody at dilution of 1:40(×200)
Immunohistochemistry of paraffin-embedded Human tonsil tissue using PLA2G16 Polyclonal Antibody at dilution of 1:40(×200)
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Overview
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Product Name
PLA2G16 Polyclonal Antibody
Catalog Number
RD253452A
Clonality
Polyclonal
Purification Method
Antigen affinity purification
Isotype
IgG
Host
Rabbit
Background
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Secretory phopholipase A2 (PLA2) enzymes cleave an acyl ester bond in the sn-2 position of glycerophospholipids. These extracellular proteins have a high disulfide bond content, low molecular mass (14 kDa), and require mM levels of Ca2+ for catalysis. They play a crucial role in the generation of arachidonates and eicosanoids, and have a number of biological actions including immunological responses, inflammation, cellular proliferation, vasoconstriction, and bronchioconstriction. Exhibits PLA1/2 activity, catalyzing the calcium-independent hydrolysis of acyl groups in various phosphatidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. Specifically catalyzes the release of fatty acids from phospholipids in adipose tissue (By similarity). N- and O-acylation activity is hardly detectable. Might decrease protein phosphatase 2A (PP2A) activity.
Immunogen Information
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Immunogen
Synthetic peptide of human PLA2G16
Swissprot
P53816
Synonyms
Adipose specific phospholipase A2Adipose specific PLA2Adipose-specific phospholipase A2AdPLACa independent phospholipase A1/2Group XVI phospholipase A1/A2Group XVI phospholipase A2H rev 107 protein homologH REV107 1H-rev 107 protein homologHRAS
Gene Accession
NP009000
Applications
Circle
Reactivity
Human, Mouse, Rat
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:30-1:150, ELISA 1:5000-1:10000
Concentration
1.1 mg/mL
Storage Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas
Circle

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