This gene encodes a pleckstrin homology domain-containing adapter protein. The encoded protein is localized to the plasma membrane where it specifically binds phosphatidylinositol 3,4-bisphosphate. This protein may be involved in the formation of signaling complexes in the plasma membrane. Polymorphisms in this gene are associated with age-related macular degeneration. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5.
Immunogen Information
Immunogen
Fusion protein of human PLEKHA1
Swissprot
Q9HB21
Synonyms
OTTHUMP00000020651PH domain containing family A member 1PH domain-containing family A member 1PKHA1Pleckstrin homology domain containing A1Pleckstrin homology domain containing family A member 1Pleckstrin homology domain containingfamily A (phosph