PLEKHG6 Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD75990A
Western Blot analysis of 231 cell using PLEKHG6 Polyclonal Antibody at dilution of 1:800
Immunohistochemistry of paraffin-embedded Human lung cancer using PLEKHG6 Polyclonal Antibody at dilution of 1:45
Immunohistochemistry of paraffin-embedded Human cervical cancer using PLEKHG6 Polyclonal Antibody at dilution of 1:45
Product Name
PLEKHG6 Polyclonal Antibody
Catalog Number
RD75990A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
PLEKHG6 functions as a guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. It activates RHOG but not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving MyoGEF, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis.
Immunogen Information
Immunogen
Recombinant protein of human PLEKHG6
Swissprot
Q3KR16
Synonyms
FLJ10665MGC126315MGC126353MGC126354Myosin interacting guanine nucleotide exchange factorPH domain containing family G member 6Pleckstrin homology domain containing family G (with RhoGef domain) member 6Pleckstrin homology domain-containing family G
Calculated MW
89 kDa
Gene Accession
BC105961
Applications
Reactivity
Human,Mouse
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:100-1:300
Concentration
0.4 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas