Mannose 6-phophate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 (RAB9A), a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo. Multiple transcript variants encoding different isoforms have been found for this gene.
Immunogen Information
Immunogen
Synthetic peptide of human PLIN3
Swissprot
O60664
Synonyms
47 kDa mannose 6-phosphate receptor-binding protein47 kDa MPR binding protein47 kDa MPR-binding proteinCargo selection protein TIP47M6PRBP 1M6PRBP1Mannose 6 phosphate receptor binding protein 1Mannose-6-phosphate receptor-binding protein 1MGC11117
Gene Accession
NP_001157661
Applications
Reactivity
Human
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.7 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4