PLN Polyclonal Antibody

For reference only. Please follow the manual included in your kit for instructions.

Catalog Number
RD90225A
Western blot analysis of extracts of various cell lines using PLN Polyclonal Antibody at 1:500 dilution.
Western blot analysis of extracts of various cell lines using PLN Polyclonal Antibody at 1:500 dilution.
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For more information on our kits, please contact us at info@reddotbiotech.com

Overview

Circle
Product Name
PLN Polyclonal Antibody
Catalog Number
RD90225A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit

Background

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The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy.

Immunogen Information

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Immunogen
A synthetic peptide of human PLN
Gene ID
5350
Swissprot
P26678
Synonyms
CMD1PCMH18PLBPLN
Calculated MW
25kDa
Observed MW
21KDa

Applications

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Reactivity
Mouse,Rat
Tested Applications
WB
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000
Concentration
1mg/mL
Storage Buffer
PBS with 0.01% thiomersal,50% glycerol,pH7.3.
Storage Instructions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

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