Pinin is a desmosomal associated protein involved with the maintenance of cell to cell adhesion of the epithelium. Pinin is a widespread protein and has been shown to play an important role in cell adhesion through its interaction with nuclear complexes. Pinin is also involved in pre-mRNA splicing through its interactions with a C-terminal RS domain of Cyclophilin G, a Moca type nuclear cyclophilin. Pinin becomes nuclear during the early stages of embryonic development and remains so throughout the entire period. Defects or lack of Pinin can be lethal at perinatal stages and causes defects in the cardiac outflow tract, axial skeleton, palate and dorsal dermis.
Immunogen Information
Immunogen
Synthetic peptide of human PNN
Swissprot
Q9H307
Synonyms
140 kDa nuclear and cell adhesion-related phosphoproteinDesmosome-associated proteinDomain-rich serine proteinDRSDRS proteinDRSPMelanoma metastasis clone A proteinMEMANuclear protein SDK3PininPININPNNSR like proteinSR-like protein
Gene Accession
NP_002678
Applications
Reactivity
Human,Mouse
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
1.2 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4