The protein encoded by this gene belongs to the evolutionary conserved polynucleotide phosphorylase family comprised of phosphate dependent 3'-to-5' exoribonucleases implicated in RNA processing and degradation. This enzyme is predominantly localized in the mitochondrial intermembrane space and is involved in import of RNA to mitochondria. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency-13 and autosomal recessive nonsyndromic deafness-70. Related pseudogenes are found on chromosomes 3 and 7.
Immunogen Information
Immunogen
Synthetic peptide of human PNPT1
Swissprot
Q8TCS8
Synonyms
3' 5' RNA exonucleaseCOXPD13DFNB70old-35OLD35PNPASEPNPase 1Polynucleotide phosphorylase like proteinPolyribonucleotide nucleotidyltransferase 1mitochondrial
Gene Accession
NP_149100
Applications
Reactivity
Human,Mouse
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.5 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4