PNRC2 Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PNRC2 Polyclonal Antibody at dilution of 1:30(×200)
Immunohistochemistry of paraffin-embedded Human liver cancer tissue using PNRC2 Polyclonal Antibody at dilution of 1:30(×200)
Product Name
PNRC2 Polyclonal Antibody
Catalog Number
RD218895A
Clonality
Polyclonal
Purification Method
Antigen affinity purification
Isotype
IgG
Host
Rabbit
Background
Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery (PubMed:19150429). May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs (PubMed:19150429). Required for UPF1/RENT1 localization to the P-body (PubMed:19150429). Plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent manner when it is bound to the 5' UTR of target mRNAs and recruiting the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Also acts as a nuclear receptor coactivator (PubMed:11574675). May play a role in controlling the energy balance between energy storage and energy expenditure (By similarity).
Immunogen Information
Immunogen
Fusion protein of human PNRC2
Swissprot
Q9NPJ4
Synonyms
0610011E17RikD4Bwg0593eFLJ20312MGC11707MGC93828MGC99541OTTMUSP00000010360OTTMUSP00000010366pnrc2PNRC2Proline rich nuclear receptor coactivator 2Proline-rich nuclear receptor coactivator 2RP11-4M23.5RP23-161N17.3
Gene Accession
BC001959
Applications
Reactivity
Human, Mouse, Rat
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:30-1:150, ELISA 1:5000-1:10000
Concentration
0.54 mg/mL
Storage Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas