This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA.
Immunogen Information
Immunogen
Recombinant fusion protein of human POLR2A (NP_000928.1).
Gene ID
5430
Swissprot
P24928
Synonyms
POLR2APOLR2POLRARPB1RPBh1RPO2RPOL2RpIILShRPB220hsRPB1Pol II