Periostin (POSTN,PN),originally named as osteoblast-specific factor 2 (OSF-2),is a 90-kDa secreted protein which is now classified as a matricellular protein. It is present in a wide variety of normal adult tissues and fetal tissues,and has a role in bone,tooth and heart development and function. Studies show that periostin is overexpressed in a broad range of human cancer types,includidng lung,ovary,breast and colon cancers. Recent evidence reveals that periostin is expressed by fibroblasts in the normal tissue and in the stroma of the primary tumour,and it is required to allow cancer stem cell maintenance.
Immunogen Information
Immunogen
Recombinant Human POSTN protein expressed by E.coli
Swissprot
Q15063
Synonyms
Fasciclin-I likeMGC119510MGC119511OSF 2OSF-2OSF2Osteoblast specific factor 2 (fasciclin I like)Osteoblast specific factor 2Osteoblast specific factorOsteoblast-specific factor 2PDLPOSTNPeriodontal ligament specific periostinPeriostinPeriostin
Applications
Reactivity
Human
Tested Applications
IHC
Conjugation
Unconjugated
Dilution
IHC 1:100-1:200
Concentration
1 mg/mL
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH 7.4
Storage Instructions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.