PPM1M Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD219190A
Immunohistochemistry of paraffin-embedded Human liver cancer tissue using PPM1M Polyclonal Antibody at dilution of 1:100(×200)
Immunohistochemistry of paraffin-embedded Human tonsil tissue using PPM1M Polyclonal Antibody at dilution of 1:100(×200)
Product Name
PPM1M Polyclonal Antibody
Catalog Number
RD219190A
Clonality
Polyclonal
Purification Method
Antigen affinity purification
Isotype
IgG
Host
Rabbit
Background
PPM1M is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase was identified as an interacting protein of Rho guanine nucleotide exchange factors (PIX). PIX proteins are regulators of p21/Cdc42/Rac1-activated kinase 1 (PAK1), a protein kinase mediating biological effects downstream of Rho GTPases. This phosphatase has been shown to block the effects of PAK, and thus inhibit actin stress fiber breakdown and morphological changes driven by cell division cycle 42 (CDC42).
Immunogen Information
Immunogen
Fusion protein of human PPM1M
Swissprot
Q96MI6
Synonyms
FLJ32332PP2C etaPP2C-etaPP2CEPP2CetaPPM1MPPM1Mprotein phosphatase 1M (PP2C domain containing)Protein phosphatase 1MProtein phosphatase 2C isoform eta
Gene Accession
BC009644
Applications
Reactivity
Human, Mouse
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:100-1:300, ELISA 1:5000-1:10000
Concentration
1.74 mg/mL
Storage Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas