RelA-associated inhibitor is a protein that in humans is encoded by the PPP1R13L gene. Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis. Interacts with RELA NF-kappa-B subunit and with SP1 via its C-terminus part. Interacts with p53/TP53, TP63 and TP73.
Immunogen Information
Immunogen
Synthetic peptide of human PPP1R13L
Swissprot
Q8WUF5
Synonyms
IASPPinhibitor of apoptosis stimulating protein of p53Inhibitor of ASPP proteinNFkB interacting protein 1NKIP1PPP1R13B-like proteinPPP1R13LProtein iASPPprotein phosphatase 1 regulatory (inhibitor) subunit 13 likeRAIRelA-associated inhibitor
Calculated MW
89 kDa
Gene Accession
NP_006654
Applications
Reactivity
Human,Mouse
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:50-1:200
Concentration
0.6 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4