PRMT5 Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD76408A
Western Blot analysis of K562, hela and 293T cell using PRMT5 Polyclonal Antibody at dilution of 1:400
Product Name
PRMT5 Polyclonal Antibody
Catalog Number
RD76408A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
Protein arginine methyltransferase 5 has been shown to interact with WD repeat-containing protein 77, CLNS1A, Janus kinase 2, SNRPD3 and SUPT5H.Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. Plays a role in the assembly of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation.
Immunogen Information
Immunogen
Synthetic peptide of human PRMT5
Swissprot
O14744
Synonyms
72 kDa ICln binding protein72 kDa ICln-binding proteinANM5Histone synthetic lethal 7S. cerevisiaehomolog ofHistone-arginine N-methyltransferase PRMT5HMT1 hnRNP methyltransferase like 5HOMOLOG OFSKB1HRMT1L5IBP72Jak-binding protein 1JBP 1JBP1
Calculated MW
71 kDa
Gene Accession
NP_001034708
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB,ELISA
Conjugation
Unconjugated
Dilution
WB 1:200-1:1000
Concentration
0.3 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas