Protein arginine methyltransferase 7is aproteinthat in humans is encoded by thePRMT7gene.Argininemethylationis an apparently irreversible protein modification catalyzed by arginine methyltransferases, such as PMT7, usingS-adenosylmethionine(AdoMet) as the methyl donor. Arginine methylation is implicated insignal transduction, RNA transport, andRNA splicing. May be involved in etoposide-induced cytotoxicity, a chemotherapeutic agent frequently used for testicular cancer and small-cell lung cancer that can cause cytotoxicity in the treatment of other cancers. Down-regulation confers increased sensitivity to the Top1 inhibitor camptothecin (CPT).
Immunogen Information
Immunogen
Recombinant protein of human PRMT7
Swissprot
Q9NVM4
Synonyms
[Myelin basic protein]-arginine N-methyltransferase PRMT7ANM7FLJ10640Histone-arginine N-methyltransferase PRMT7KIAA1933Myelin basic protein arginine N methyltransferaseOTTHUMP00000174863PRMT7Protein arginine methyltransferase 7Protein arginine N-
Calculated MW
78 kDa
Gene Accession
BC000146
Applications
Reactivity
Human
Tested Applications
WB,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000
Concentration
0.2 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4