PSENEN Polyclonal Antibody

For reference only. Please follow the manual included in your kit for instructions.

Catalog Number
Western blot analysis of extracts of various cell lines using PSENEN Polyclonal Antibody at dilution of 1:1000.
Western blot analysis of extracts of various cell lines using PSENEN Polyclonal Antibody at dilution of 1:1000.
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Overview

Circle
Product Name
PSENEN Polyclonal Antibody
Catalog Number
RD266448A
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit

Background

Circle
Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants.

Immunogen Information

Circle
Immunogen
A synthetic peptide of human PSENEN (NP_758844.1).
Gene ID
55851
Swissprot
Q9NZ42
Synonyms
PSENENMDS033MSTP064PEN-2PEN2
Calculated MW
12 kDa
Observed MW
16 kDa

Applications

Circle
Reactivity
Human,Mouse,Rat
Tested Applications
WB
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000
Concentration
1 mg/mL
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.

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