The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses.
Immunogen Information
Immunogen
Synthetic peptide of human PTGER4
Swissprot
P35408
Synonyms
EP 4EP4EP4RMGC126583PE2R4PGE receptor EP4 subtypePGE2 receptor EP4 subtypeProstaglandin E receptor 4Prostaglandin E receptor 4 subtype EP4Prostaglandin E2 receptorProstaglandin E2 receptor EP4 subtypeProstanoid EP4 receptorPTGER 2PTGER 4PTGE
Calculated MW
53 kDa
Gene Accession
NP_000949
Applications
Reactivity
Human
Tested Applications
WB,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000
Concentration
0.6 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4