PTN Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD76546A
Western Blot analysis of Human colon cancer tissue using PTN Polyclonal Antibody at dilution of 1:600
Product Name
PTN Polyclonal Antibody
Catalog Number
RD76546A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
Pleiotrophin(PTN) also known asheparin-binding brain mitogen(HBBM) orheparin-binding growth factor 8(HBGF-8) orneurite growth-promoting factor 1(NEGF1) orheparin affinity regulatory peptide(HARP) orheparin binding growth associated molecule(HB-GAM) is aproteinthat in humans is encoded by thePTNgene.Pleiotrophin is an 18-kDagrowth factorthat has a high affinity forheparin. It is structurally related tomidkineandretinoic acid induced heparin-binding protein. Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation.
Immunogen Information
Immunogen
Synthetic peptide of human PTN
Swissprot
P21246
Synonyms
HARPHB-GAMHBBMHBGAMHBGF-8HBGF8HBNFHBNF-1HBNF1heparin affin regulatory proteinHeparin binding growth associated moleculeHeparin binding growth factor 8Heparin binding neurite outgrowth promoting factor 1Heparin-binding brain mitogenHeparin-bi
Calculated MW
19 kDa
Gene Accession
NP_002816
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000
Concentration
0.3 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas