The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis.
Immunogen Information
Immunogen
Synthetic peptide of human PTPN12
Swissprot
Q05209
Synonyms
Protein tyrosine phosphatase G1Protein tyrosine phosphatase non receptor type 12Protein-tyrosine phosphatase G1PTN12PTP PESTPTP-PESTPTPG1Ptpn12Tyrosine protein phosphatase non receptor type 12Tyrosine-protein phosphatase non-receptor type 12
Calculated MW
88 kDa
Gene Accession
NP_001124480
Applications
Reactivity
Human,Mouse
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:200-1:1000, IHC 1:100-1:300
Concentration
1 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4