Promotes caspase-mediated apoptosis. This proapoptotic activity is mediated predominantly through the activation of caspase-9. May be a component of the inflammasome, a protein complex which also includes NALP2, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases.
Immunogen Information
Immunogen
Synthesized peptide derived from the N-terminal region of human ASC
Swissprot
Q9ULZ3
Synonyms
Apoptosis associated speck like protein containing a CARDApoptosis-associated speck-like protein containing a CARDASCASCCARD 5CARD5Caspase recruitment domain containing protein 5Caspase recruitment domain protein 5Caspase recruitment domain-contai
Calculated MW
22 kDa
Observed MW
21 kDa
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB,IHC-p,IF,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:40000
Concentration
1 mg/mL
Storage Buffer
PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4