RAC2,also named as GX,belongs to the small GTPase superfamily and Rho family. RAC2 is a plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses,such as secretory processes,phagocytose of apoptotic cells and epithelial cell polarization. RAC2 augments the production of reactive oxygen species (ROS) by NADPH oxidase. Defects in RAC2 are the cause of neutrophil immunodeficiency syndrome.
Immunogen Information
Immunogen
Synthetic peptide of human RAC2
Swissprot
P15153
Synonyms
EN 7EN-7EN7GXHSPC 022HSPC022p21 Rac 2p21 Rac2p21-Rac2p21Rac2RAC 2Rac2RAC2Ras related C3 botulinum toxin substrate 2 (rho familysmall GTP binding protein Rac2Ras related C3 botulinum toxin substrate 2Ras related C3 botulinum toxin substrate