RAD50 Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD79963A
Western blot analysis of extracts of various cell lines using RAD50 Polyclonal Antibody at dilution of 1:500.
Immunohistochemistry of paraffin-embedded Human breast cancer using RAD50 Polyclonal Antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded Human stomach using RAD50 Polyclonal Antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded Human gastric cancer using RAD50 Polyclonal Antibody at dilution of 1:100 (40x lens).
Variation
Quantity
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Overview
Product Name
RAD50 Polyclonal Antibody
Catalog Number
RD79963A
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.
Immunogen Information
Immunogen
A synthetic peptide of human RAD50
Gene ID
10111
Swissprot
Q92878
Synonyms
RAD50NBSLDRAD502hRad50
Calculated MW
138 kDa/153 kDa/154 kDa
Observed MW
180 kDa
Applications
Reactivity
Human,Mouse
Tested Applications
WB,IHC
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000 IHC 1:50-1:100
Concentration
1 mg/mL
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas