The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface.
Immunogen Information
Immunogen
Synthetic peptide of human RAMP2
Swissprot
O60895
Synonyms
Calcitonin receptor like receptor activity modifying protein 2Calcitonin-receptor-like receptor activity-modifying protein 2CRLR activity modifying protein 2CRLR activity-modifying protein 2OTTMUSP00000002615OTTMUSP00000037624RAMP2RAMP2Receptor (c
Calculated MW
20 kDa
Gene Accession
NP_005845
Applications
Reactivity
Human
Tested Applications
WB,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000
Concentration
0.5 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4