The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This family member is an inositol 1,3,4,5-tetrakisphosphate-binding protein, like the closely related RAS p21 protein activator 2.
Immunogen Information
Immunogen
Synthetic peptide of human RASA3
Swissprot
Q14644
Synonyms
GAP IIIGAP1(IP4BP)GAP1IP4BPGAPIIIGTPase activating protein 1 familyGTPase activating protein IIIInositol 1 3 4 5 tetrakisphosphate binding proteinInositol 1345 tetrakisphosphate binding proteinIns P4 binding proteinIns P4-binding proteinIns(1 3
Gene Accession
NP_031394
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:30-1:150
Concentration
0.4 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4