This gene encodes a member of the Ras-assocation domain family (RASSF) of tumor suppressor proteins. This gene is essential for maintaining adherens junction function in epithelial cells and has a role in epithelial cell migration. It is a lung tumor suppressor gene candidate. A chromosomal translocation t(12;22)(p11.2;q13.3) leading to the fusion of this gene and the FBLN1 gene is found in a complex type of synpolydactyly. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Immunogen Information
Immunogen
Fusion protein of human RASSF8
Swissprot
Q8NHQ8
Synonyms
C12orf2Carcinoma associated HOJ 1Carcinoma associated protein HOJ 1Carcinoma-associated protein HOJ-1HoJ 1HoJ1Ras association (RalGDS/AF 6) domain family (N terminal) member 8Ras association (RalGDS/AF 6) domain family 8Ras association domain cont