The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.
Immunogen Information
Immunogen
Recombinant protein of human RBBP8
Swissprot
Q99708
Synonyms
COM1COM1CtBP interacting proteinCtBP-interacting proteinCtIPDNA endonuclease RBBP8JWDSRB binding protein 8 endonucleaseRBBP-8RBBP8Retinoblastoma-binding protein 8Retinoblastoma-interacting protein and myosin-likeRimSAE2SCKL2Sporulation in t
Gene Accession
BC030590
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:100-1:300
Concentration
0.6 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4