RBL2 Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using RBL2 Polyclonal Antibody at dilution of 1:45(×200)
Product Name
RBL2 Polyclonal Antibody
Catalog Number
RD219324A
Clonality
Polyclonal
Purification Method
Antigen affinity purification
Isotype
IgG
Host
Rabbit
Background
Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
Immunogen Information
Immunogen
Synthetic peptide of human RBL2
Swissprot
Q08999
Synonyms
130 kDa retinoblastoma associated protein130 kDa retinoblastoma-associated proteinIB4p130PPAR-alpha-interacting complex protein 128PRB2Rb2Rbl2RBL2RBR 2RBR-2RBR2Retinoblastoma like 2Retinoblastoma-like protein 2Retinoblastoma-related protein
Gene Accession
NP005602
Applications
Reactivity
Human, Mouse, Rat
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:30-1:150, ELISA 1:5000-1:10000
Concentration
0.8 mg/mL
Storage Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas