RBM7 Polyclonal Antibody

For reference only. Please follow the manual included in your kit for instructions.

Catalog Number
RD88869A
Western blot analysis of extracts of various cell lines using RBM7 Polyclonal Antibody at 1:1000 dilution.
Western blot analysis of extracts of various cell lines using RBM7 Polyclonal Antibody at 1:1000 dilution.
Western blot analysis of extracts of Mouse thymus using RBM7 Polyclonal Antibody at 1:1000 dilution.
Western blot analysis of extracts of Mouse thymus using RBM7 Polyclonal Antibody at 1:1000 dilution.
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Overview

Circle
Product Name
RBM7 Polyclonal Antibody
Catalog Number
RD88869A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit

Background

Circle
RNA-binding subunit of the trimeric nuclear exosome targeting (NEXT complex, a complex that functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs. Binds preferentially polyuridine sequences and associates with newly synthesized RNAs, including pre-mRNAs and short-lived exosome substrates such as promoter upstream transcripts (PROMPTs, enhancer RNAs (eRNAs, and 3'-extended products from small nuclear RNAs (snRNAs. Participates in several biological processes including DNA damage response (DDR and stress response. During stress response, activation of the p38MAPK-MK2 pathway decreases RBM7-RNA-binding and subsequently the RNA exosome degradation activities, thereby modulating the turnover of non-coding transcriptome. Participates in DNA damage response (DDR, through its interaction with MEPCE and LARP7, the core subunits of 7SK snRNP complex, that release the positive transcription elongation factor b (P-TEFb complex from the 7SK snRNP. In turn, activation of P-TEFb complex induces the transcription of P-TEFb-dependent DDR genes to promote cell viability.

Immunogen Information

Circle
Immunogen
Recombinant fusion protein of human RBM7
Gene ID
10179
Swissprot
Q9Y580
Synonyms
RBM7
Calculated MW
14kDa/22kDa/43kDa
Observed MW
22kDa

Applications

Circle
Reactivity
Human,Mouse
Tested Applications
WB
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000
Concentration
1mg/mL
Storage Buffer
PBS with 0.01% thiomersal,50% glycerol,pH7.3.
Storage Instructions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

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