The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including TP53, HDAC1 and CDKN1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Immunogen Information
Immunogen
Fusion protein of human RCHY1
Swissprot
Q96PM5
Synonyms
Androgen receptor N terminal interacting proteinAndrogen receptor N-terminal-interacting proteinARNIPCH-rich-interacting match with PLAG1CHIMPE3 ubiquitin-protein ligase Pirh2hARNIPhPirh2p53 induced protein with a RING H2 domainp53-induced RING-H