Recombinant Doublecortin Monoclonal Antibody

For reference only. Please follow the manual included in your kit for instructions.

Catalog Number
RD87025A
Western blot detection of Doublecortin in Rat Brain cell using Doublecortin Rabbit mAb(1:1000 diluted).Predicted band size:41kDa.Observed band size:41kDa.
Western blot detection of Doublecortin in Rat Brain cell using Doublecortin Rabbit mAb(1:1000 diluted).Predicted band size:41kDa.Observed band size:41kDa.
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Overview

Circle
Product Name
Recombinant Doublecortin Monoclonal Antibody
Catalog Number
RD87025A
Clonality
Monoclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit

Background

Circle
This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, cognitive disability, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene.

Immunogen Information

Circle
Immunogen
Recombinant protein of human Doublecortin
Gene ID
1641
Swissprot
O43602
Synonyms
DBCNDbctDCDCXDCXDoublecortexDoublinFLJ51296Lis XLis-XLissencephalin XLissencephalin-XLissencephaly X linkedLissencephaly X linked doublecortinLISXNeuronal migration protein doublecortinOTTHUMP00000023859OTTHUMP00000023860OTTHUMP000002163
Calculated MW
47kDa
Observed MW
70kDa

Applications

Circle
Reactivity
Rat
Tested Applications
WB
Conjugation
Unconjugated
Dilution
WB 1:500-1:1000
Concentration
300 μg/mL
Storage Buffer
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein
Storage Instructions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

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