Recombinant LRP1 Monoclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD87052A
Western blot detection of LRP1 in Rat Brain,C6 cell lysates using LRP1 Rabbit mAb(1:1000 diluted).Predicted band size:85kDa.Observed band size:85kDa.
Immunohistochemistry of LRP1 in paraffin-embedded Human Cholangiocarcinoma using LRP1 Rabbit mAb at dilution 1:20
Product Name
Recombinant LRP1 Monoclonal Antibody
Catalog Number
RD87052A
Clonality
Monoclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients.
Immunogen Information
Immunogen
A synthetic peptide of human LRP1
Gene ID
4035
Swissprot
Q07954
Synonyms
LRP1A2MRAPOERAPRCD91IGFBP3RKPALRPLRP1ATGFBR5
Calculated MW
50kDa
Observed MW
50kDa
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB,IHC-P
Conjugation
Unconjugated
Dilution
WB 1:1000-1:2000, IHC 1:20-1:100
Concentration
300 μg/mL
Storage Buffer
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein
Storage Instructions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.