Recombinant Presenilin 1 Monoclonal Antibody

For reference only. Please follow the manual included in your kit for instructions.

Catalog Number
Western blot detection of Presenilin 1/PS-1 in Hela,C6,Jurkat cell lysates using Presenilin 1/PS-1 Rabbit mAb(1:500 diluted).Predicted band size:53kDa.Observed band size:20kDa.
Western blot detection of Presenilin 1/PS-1 in Hela,C6,Jurkat cell lysates using Presenilin 1/PS-1 Rabbit mAb(1:500 diluted).Predicted band size:53kDa.Observed band size:20kDa.
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Overview

Circle
Product Name
Recombinant Presenilin 1 Monoclonal Antibody
Catalog Number
RD87072A
Clonality
Monoclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit

Background

Circle
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.

Immunogen Information

Circle
Immunogen
A synthetic peptide of human Presenilin 1
Gene ID
5663
Swissprot
P49768
Synonyms
AD3FADPS-1PS1S182Presenilin 1PSEN1
Calculated MW
79kDa
Observed MW
79kDa

Applications

Circle
Reactivity
Human,Mouse,Rat
Tested Applications
WB
Conjugation
Unconjugated
Dilution
WB 1:1000-1:2000
Concentration
300 μg/mL
Storage Buffer
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein
Storage Instructions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

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