The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene.
Immunogen Information
Immunogen
A synthetic peptide of human Superoxide Dismutase 1
Gene ID
6647
Swissprot
P00441
Synonyms
ALSALS1Amyotrophic lateral sclerosis 1 adultCu/Zn SODCu/Zn superoxide dismutaseEpididymis secretory protein Li 44HEL S 44HomodimerhSod1Indophenoloxidase AIPOAMn superoxide dismutaseSODSOD solubleSOD1SOD2SODCSODCSuperoxide dismutase [Cu-Z
Calculated MW
16kDa
Observed MW
16kDa
Applications
Reactivity
Human,Rat
Tested Applications
WB,IHC-P
Conjugation
Unconjugated
Dilution
WB 1:500-1:1000, IHC 1:50-1:100
Concentration
300 μg/mL
Storage Buffer
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein
Storage Instructions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.